Related Experiment Video
Updated: Aug 17, 2025
02:49
Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
1.2K
Topical Hemostatic Agents in Burn Surgery: A Systematic Review
Andrea Battistini1, Lawrence J Gottlieb1, Sebastian Q Vrouwe1
1Section of Plastic & Reconstructive Surgery, University of Chicago, Chicago, IL, USA.
Summary
Topical hemostatic agents are used in burn surgery to control bleeding, but current data is limited. High-quality research is needed to determine the best agents and methods for effective hemorrhage control.
Area of Science:
- Surgery
- Anesthesiology
- Wound Healing
Background:
- Intra-operative bleeding is a significant challenge in acute burn surgery.
- Existing hemostatic techniques include tourniquets, tumescent infiltration, and topical agents.
- A comprehensive review of topical hemostatic agents in burn surgery is lacking.
Approach:
- A systematic review was conducted using PubMed, Scopus, and Web of Science up to September 10, 2021.
- Included studies evaluated topical hemostatic agents in burn excision and/or grafting.
- Data extracted included agent type, dosage, delivery, hemostasis outcomes, and complications.
Key Points:
- 1982 citations were identified, with 49 studies meeting inclusion criteria.
- Common agents included vasoconstrictors (e.g., epinephrine) and procoagulants (e.g., thrombin).
- Low-quality evidence (94% level III-V) and inconsistent reporting hinder optimal agent determination.
Conclusions:
- Determining the optimal topical hemostatic agent is challenging due to limited high-quality data.
- Consistent reporting of intra-operative blood loss is needed for comparative analysis.
- Future high-quality research is essential to guide the selection of topical hemostatic agents in burn surgery.
Related Concept Videos
01:22Burn Injuries
2.7K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.7K
01:05Introduction to Hemostasis
8.5K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.5K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
8.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
8.7K
01:29Venous Thrombosis III: Interprofessional Care
16
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
16
01:28Esophageal Varices-II: Clinical Features and Management
118
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
118
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
827
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
827