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Altered functional connectivity during performance feedback processing in multiple sclerosis.

Christopher J Cagna1, Ahmet O Ceceli2, Joshua Sandry3

  • 1Department of Psychology, Rutgers University - Newark, 101 Warren Street, Newark, NJ 07102, United States.

Neuroimage. Clinical
|December 14, 2022
PubMed
Summary
This summary is machine-generated.

People with multiple sclerosis (MS) show preserved feedback-based learning despite cognitive fatigue (CF). MS patients may use alternative brain connections for learning, suggesting potential for cognitive rehabilitation.

Keywords:
Cognitive fatigueFeedbackMultiple sclerosisRewardStriatumfMRI

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Clinical Neurology

Background:

  • Effective learning from performance feedback is crucial for cognitive performance and adaptive behavior.
  • Multiple sclerosis (MS) is associated with cognitive dysfunction, particularly cognitive fatigue (CF), impacting cortico-striatal regions vital for feedback learning.
  • Understanding feedback-based learning in MS, its neural basis, and CF's influence is lacking.

Purpose of the Study:

  • To investigate feedback-based learning ability in individuals with MS.
  • To examine the associated cortico-striatal function and connectivity during feedback processing in MS.
  • To determine the impact of cognitive fatigue (CF) on feedback-based learning in MS.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to assess brain activity during a paired-word association task.
  • Participants (MS and neurotypical [NT]) received monetary, non-monetary, and uninformative feedback.
  • Task performance, subjective cognitive fatigue, and functional connectivity were analyzed.

Main Results:

  • MS participants exhibited comparable task performance to NTs, despite reporting higher CF.
  • Both groups recruited common cortico-striatal regions (ventral striatum, caudate, ventromedial prefrontal cortex) for feedback processing.
  • MS participants showed enhanced functional connectivity between the ventral striatum and other brain regions (angular gyrus, superior temporal gyrus) during feedback receipt.

Conclusions:

  • Cognitive fatigue (CF) may not impede feedback-based learning in individuals with MS.
  • People with MS might utilize alternative neural pathways involving the striatum for feedback-based learning.
  • Findings suggest potential for cognitive rehabilitation strategies leveraging performance feedback in MS and other clinical populations.