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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
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Estrogen-DNA Adducts and Breast Cancer Risk in Premenopausal Asian Women
Ching-Hung Lin1,2, Muhammad Zahid3, Wen-Hung Kuo4
1Department of Medical Oncology, National Taiwan University Hospital, Cancer Center Branch, Taipei, Taiwan.
Cancer Prevention Research (Philadelphia, Pa.)
|December 14, 2022
Summary
Elevated estrogen-DNA adducts in premenopausal women are linked to increased breast cancer risk. This finding suggests endogenous estrogen genotoxicity may play a role in breast cancer development in East Asian populations.
Area of Science:
- Oncology
- Genetics
- Endocrinology
Background:
- Breast cancer incidence is rising among premenopausal women in East Asia.
- Estrogen metabolism and its role in DNA damage are implicated in breast carcinogenesis.
Purpose of the Study:
- To investigate the association between estrogen-DNA adducts and breast cancer risk in premenopausal Taiwanese women.
- To explore the potential role of estrogen-induced genotoxicity in breast cancer development.
Main Methods:
- A case-control study involving 221 breast cancer/proliferative benign breast disease cases and 146 controls.
- Plasma estrogen-DNA adduct ratios were analyzed using ultraperformance LC/MS-MS.
- Genotyping of CYP1A1, CYP1B1, and COMT single nucleotide polymorphisms (SNPs).
Main Results:
- The estrogen-DNA adduct ratio was significantly higher in the case group compared to the control group (median 58.52 vs. 29.36, P = 0.004).
- A higher estrogen-DNA adduct ratio was a significant predictor of breast cancer risk (HR=1.718, P < 0.001).
- No association was found between CYP1A1, CYP1B1, and COMT SNPs and estrogen-DNA adduct ratios.
Conclusions:
- Plasma estrogen-DNA adduct ratio is associated with breast cancer or proliferating benign breast disease in premenopausal Taiwanese women.
- Endogenous estrogen-induced genotoxicity may contribute to breast cancer carcinogenesis in premenopausal Asian women.
- This research has potential preventive implications for the rising incidence of breast cancer in East Asia.
