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The JAK-STAT Signaling Pathway in Epilepsy

Huaiyu Sun1, Di Ma1, Yu Cheng1

  • 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Current Neuropharmacology
|December 15, 2022
PubMed

Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence that inflammatory mediators and immune cells are involved in epileptic seizures. As more research is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of epilepsy will be revealed. The Janus kinase-signal transducer and transcriptional activator (JAKSTAT) signaling pathway is strongly associated with many immune and inflammatory diseases, At present, more and more studies have found that the JAK-STAT pathway is involved in the development and development of epilepsy, indicating the JAK-STAT pathway's potential promise as a target in epilepsy treatment. In this review, we discuss the composition, activation, and regulation of the JAK-STAT pathway and the relationship between the JAK-STAT pathway and epilepsy. In addition, we summarize the common clinical inhibitors of JAK and STAT that we would expect to be used in epilepsy treatment in the future.

Keywords:
CytokinesGABAJAK-STATepilepsyseizuressignaling pathways

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