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Gene polymorphism among hypertensive patients with coronary artery disease

D Selvakumar1, C K Vijayasamundeeswari1, E Gnanadesigan2

  • 1Department of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical college and Hospitals, Salem, Vinayaka Mission's Research Foundation (Deemed to be University), Salem -636 308, Tamilnadu, India.

Bioinformation
|December 15, 2022
PubMed

Insights

Interleukin-6 (IL-6) gene polymorphisms, specifically the GG genotype at IL-6 -174 and IL-6 -572C/G, are significantly associated with coronary artery disease (CAD) in hypertensive patients. These findings suggest a genetic link to CAD development in this population.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Coronary Artery Disease (CAD) results from coronary artery obstruction.
  • Interleukin-6 (IL-6) is implicated in cardiovascular diseases like atherosclerosis and CAD.
  • Limited research exists on the IL-6 gene's role in CAD among hypertensive individuals.

Purpose of the Study:

  • To investigate the association between IL-6 gene polymorphisms and coronary artery disease (CAD) in patients with hypertension.
  • To explore specific IL-6 gene variants and their prevalence in CAD cases versus controls.

Main Methods:

  • Utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze IL-6 gene polymorphisms.
  • Employed chi-square analysis to determine statistical significance of the findings.
  • Compared genotype and allele frequencies between CAD patients and control groups.

Main Results:

  • The GG genotype of IL-6 -174 was significantly more frequent in CAD patients (48.67%) than controls (8%).
  • The GG genotype of IL-6 -572C/G polymorphism was also more prevalent in CAD cases (42.6%) compared to controls (8%).
  • A significant association was observed between the variant allele G and CAD patients, with hypertension being more common in cases.

Conclusions:

  • IL-6 gene polymorphisms, particularly the GG genotype at -174 and -572C/G, may be associated with the development of CAD in hypertensive individuals.
  • These genetic variations could serve as potential biomarkers for CAD risk in this patient group.
  • Further research is warranted to elucidate the precise mechanisms linking IL-6 gene polymorphisms to CAD pathogenesis in hypertension.

Keywords:
CADIL-6 -174IL-6-572gene polymorphismhypertension

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