Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Packaging

DNA Packaging

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated physiological, transcriptomic, and metabolomic analysis of exogenous trehalose regulating cold tolerance in grape callus.

BMC plant biology·2026

Same author

Genomic analysis of oesophageal carcinoma (EC) identifies recurrent mutations in histone methyltransferases as a distinctive subset.

Oncogene·2026

Same author

Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer.

Research square·2026

Same author

The IGF1-PGM5 Axis Inhibits Aerobic Glycolysis and Serves As a Tumor Suppressor in Nasopharyngeal Carcinoma.

Journal of biochemical and molecular toxicology·2026

Same author

Supratopological Ion-Coordinated Binder Networks for Durable and Kinetically Efficient Silicon Anodes.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Research on the scheme of a CNN-based differential modulation and detection in optical wireless communication with atmospheric turbulence.

Optics express·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

DNA origami tubes with reconfigurable cross-sections.

Anjelica Kucinic¹, Chao-Min Huang², Jingyuan Wang²

¹Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA.

|December 15, 2022

Summary

Researchers developed a novel DNA origami 6-bar mechanism for advanced shape-morphing assemblies. This DNA nanotechnology innovation enables complex reconfigurable materials for sensing and tunable properties at the nano to micron scale.

More Related Videos

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

Area of Science:

Structural DNA nanotechnology
Nanoscale engineering
Materials science

Background:

DNA nanotechnology enables precise nanoscale structure design with dynamic and mechanical properties.
Advances in DNA origami actuation and assembly allow for shape-morphing materials.
Existing reconfigurable DNA devices exhibit limited motion, primarily simple hinges.

Purpose of the Study:

To develop advanced shape-changing capabilities in DNA origami assemblies.
To create a multi-component DNA origami 6-bar mechanism for diverse shape transformations.
To integrate reconfigurable DNA devices into larger, functional assemblies.

Main Methods:

Designed and constructed a multi-component DNA origami 6-bar mechanism.
Demonstrated folding into four distinct shapes and transitions between them.
Investigated shape preferences via competitive folding reactions to determine relative free energies.
Polymerized mechanisms into tubes with shape-defined cross-sections and demonstrated shape changes.

Main Results:

Successfully folded the 6-bar mechanism into four different shapes with multiple transitions.
Gained insights into the relative free energies of different mechanism shapes.
Created polymerised tubes with tunable cross-sections by controlling individual mechanism shapes.

Conclusions:

The developed 6-bar mechanism significantly expands shape-changing capabilities beyond simple hinges.
This work provides a foundation for nano to micron scale DNA nanotechnology applications.
Enables future applications in biosensing and materials with tunable properties.