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Updated: Aug 17, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
How decreasing T cell signaling unexpectedly results in autoimmunity
1Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Abstract:
In this issue of JEM, Tanaka et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220386) advance our understanding of how genetic mutants that decrease T cell recognition of antigen, a critical event for immune activation to invading microbes and virus, paradoxically results in autoimmunity.
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