Related Experiment Video
Updated: Aug 17, 2025
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Increased Risk of Neurological Disease Following Pediatric Rotavirus Infection: A Two-Center Case-Control Study
Xiaoyan Xu1, Yunjiao Luo2, Canlin He3
1Department of Pediatrics, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan Province, China.
Insights
Pediatric rotavirus infection significantly increases the risk of neurological disease and other extraintestinal complications in children. These complications lead to poorer clinical outcomes and prolonged hospital stays.
Area of Science:
- Pediatric infectious diseases
- Gastroenterology
- Neurology
Background:
- The association between pediatric rotavirus infection and extraintestinal complications is not well-established.
- Investigating these complications is crucial for understanding the full impact of rotavirus in young children.
Purpose of the Study:
- To determine the incidence and risks of extraintestinal complications, particularly neurological disease, associated with rotavirus infection in hospitalized children under five.
- To analyze the clinical outcomes and hospitalization impact of rotavirus infection and its complications.
Main Methods:
- A case-control study was conducted involving hospitalized children under five years old.
- 1325 children with rotavirus infection were compared to 1840 controls without rotavirus infection.
- Statistical analyses, including odd ratios and confounder adjustment, were used to assess risks.
Main Results:
- Rotavirus infection was significantly associated with higher incidences of neurological disease in both newborns and older infants/children.
- The adjusted odd ratios for neurological disease were 2.56 in newborns and 1.85 in infants and young children.
- Other extraintestinal complications were also observed, varying by population and disease severity, impacting hospitalization and discharge outcomes.
Conclusions:
- Rotavirus exposure is linked to a range of extraintestinal complications, with neurological disease being prominent.
- Rotavirus infection and its sequelae contribute to adverse clinical outcomes in pediatric patients.
- Early identification and management of rotavirus-associated complications are essential for improving patient prognosis.
Background:
Whether pediatric rotavirus infection is associated with extraintestinal complications remains unknown.
Methods:
We conducted a case-control study to investigate the incidences and risks of rotavirus-associated extraintestinal complications in hospitalized newborns, infants, and children younger than 5 years.
Results:
A total of 1325 young inpatients with rotavirus infection (754 male and 539 newborns) and 1840 controls without rotavirus infection (1035 male and 836 newborns) were included. The incidences of neurological disease were higher among rotavirus individuals compared with controls: newborns, 7.24% (39/539) versus 2.87% (24/836), P < .001; infants and young children, 19.59% (154/786) versus 12.35% (124/1004), P < .001. The associated odd ratios (ORs) for neurological disease frequency following rotavirus infection was 2.64 (95% confidence interval [CI], 1.57-4.44) for newborns and 1.73 (95% CI, 1.34-2.24) for infants and young children, which increased to 2.56 (95% CI, 1.57-4.18) in case-control (1:1) matching analysis and 1.85 (95% CI, 1.41-2.42) in confounder adjustment. Rotavirus infection was associated with other extraintestinal complications, depending on study population and disease severity. Outcome analysis revealed rotavirus infection and its consequences had a significant impact on hospitalization and discharge.
Conclusions:
Rotavirus exposure was associated with a spectrum of extraintestinal complications, particularly neurological disease. Rotavirus infection and subsequent consequences resulted in poor clinical outcomes.
Related Concept Videos
01:28Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...