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Culture and Co-Culture of Mouse Ovaries and Ovarian Follicles
Published on: March 17, 2015
Effects of ingested gossypol on the ultrastructure of rat ovarian follicles
L C Pan1, M J Nadakavukaren, D R Jensen
1Department of Biological Sciences, Illinois State University, Normal 61761.
Abstract:
Ultrastructural changes were observed in the oocytes and granulosa cells of the ovarian follicles of sexually mature female rats treated daily for 60 days with gossypol acetic acid at a dosage known to induce sterility in male rats (20 mg/kg body weight, orally). The changes included an increased lysosomal population in the ooplasm and a reduced, poorly developed smooth endoplasmic reticulum in the granulosa cells. The latter changes suggest a suppression of the secretory activity of the granulosa cells.
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