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Oxygen-generating polymer vesicles for enhanced sonodynamic tumor therapy.

Ping Wei1, Shuai Chen2, Junqiu Shi2

  • 1Department of Gynaecology and Obstetrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China; Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China; School of Life Sciences and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 15, 2022
PubMed
Summary

This study developed oxygen-generating polymer vesicles for enhanced sonodynamic therapy (SDT). The novel Ce6-MnO2-PVs effectively eradicated tumors and reduced tumor progression factors in vivo.

Keywords:
HypoxiaManganese dioxidePolymer vesiclesSelf-assemblySonodynamic therapy

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Cancer Therapy

Background:

  • Sonodynamic therapy (SDT) efficacy is hindered by poor sonosensitizer solubility and tumor hypoxia.
  • Hypoxic tumors present a significant challenge for conventional cancer treatments.

Purpose of the Study:

  • To develop an oxygen-generating polymer vesicle system for enhanced SDT.
  • To overcome limitations of insolubility and tumor hypoxia in SDT.

Main Methods:

  • Synthesized polymer vesicles encapsulating manganese dioxide and chlorine e6 (Ce6-MnO2-PVs).
  • Evaluated catalase mimetic activity and reactive oxygen species generation upon ultrasound activation.
  • Assessed in vivo anti-tumor efficacy and effects on tumor progression factors (hypoxia-inducible factor-1α, vascular endothelial growth factor).

Main Results:

  • Ce6-MnO2-PVs demonstrated high catalase mimetic activity and efficient reactive oxygen species generation.
  • In vivo studies showed 94% tumor volume reduction with Ce6-MnO2-PVs, indicating significant anti-tumor efficacy.
  • Reduced expression of hypoxia-inducible factor-1α (66%) and vascular endothelial growth factor (52%) was observed post-injection.

Conclusions:

  • Ce6-MnO2-PVs represent a promising platform for overcoming SDT limitations in hypoxic tumors.
  • The developed system shows potential for effective and safe enhanced sonodynamic therapy.
  • This approach offers a novel strategy for cancer treatment by addressing tumor microenvironment challenges.