Relationships between chemical structure and adverse effects of antibacterial and antifungal agents

Chemical structure and adverse effects are presented, including the side chains responsible for platelet inhibitory effects, hypoprothrombinemic effects, the disulfiram effect of some betalactams as well as the structures responsible for the hemotoxic effects of chloramphenicol, the digestive intolerance and hepatotoxic effect of some macrolides, the neurotoxic effects of quinolones, the nephrotoxicity of amphotericin, aminoglycosides, and polymyxin B - colistin. The conclusions to be derived by the prescribing physician are discussed in relation with these aspects.