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Updated: Aug 17, 2025

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
Chemoselective and Enantioselective Fluorescent Recognition of Prolinol
Yixuan Jiang1, Jun Tian1, Hongyu Guo1
1Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Abstract:
A highly chemoselective and enantioselective fluorescent probe has been discovered for the recognition of prolinol among various primary and secondary amine-based amino alcohols. The mechanistic studies including 1D and 2D 1H/13C NMR and mass spectroscopic analyses and DFT calculations have shown that the aldehyde group of the probe can react with prolinol to generate a bicyclic oxazolidine unit which, through a possible intramolecular hydrogen bond interaction, will lead to highly selective fluorescence enhancement.
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