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Biosensor integrated tissue chips and their applications on Earth and in space
Anne Yau1, Zizheng Wang2, Nadya Ponthempilly1
1Department of Biomedical Engineering, University of Connecticut, Storrs, CT, 06296, USA.
Biosensors & Bioelectronics
|December 17, 2022
Summary
Tissue chips with biosensors are being developed to study human biology in space and improve drug development. These advanced models leverage microgravity to assess cellular functions and disease mechanisms for Earth and space applications.
Area of Science:
- Biomedical Engineering
- Space Biology
- Drug Development
Background:
- Space exploration technologies offer numerous benefits to Earth life.
- Human physiology is significantly altered by spaceflight, posing challenges for astronaut health.
- Current drug development models often fail due to a lack of efficacy and toxicity, highlighting the need for better predictive tools.
Approach:
- Developing advanced tissue chips (organ-on-a-chip) integrated with biosensors.
- Utilizing the International Space Station (ISS) to study microgravity's effects on human cells and tissues.
- Leveraging collaborations between CASIS, NASA, NIH, and NSF to advance research.
Key Points:
- Tissue chips with biosensors enable real-time monitoring of cellular microenvironments in space.
- Microgravity provides a unique environment to study human biology, physiology, and disease.
- These models can improve the accuracy and efficiency of therapeutic drug development.
Conclusions:
- Space-based tissue chip technology offers a powerful platform for understanding human health in extreme environments.
- This research has the potential to accelerate drug discovery and improve treatments for diseases on Earth.
- Future perspectives include expanded applications of tissue chips in both space exploration and terrestrial medicine.
