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Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition.

Yue Liu1, Abudureyimu Abula2, Haonan Xiao1

  • 1The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Institute of Viruses and Infectious Diseases, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University, Nanjing, People's Republic of China.

Journal of Molecular Biology
|December 17, 2022
PubMed
Summary

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) acts as a DNA sensor. This study reveals how U-shaped DNA binding induces hnRNP A2/B1 homodimerization, crucial for antiviral responses.

Keywords:
RRMs domainU-shaped DNAcrystal structurehnRNP A2/B1homodimerization

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