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The novel importance of miR-143 in obesity regulation

Jie Liu1, Huan Wang1, Dewei Zeng1

  • 1Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.

International Journal of Obesity (2005)
|December 17, 2022
PubMed

Insights

MicroRNA-143 (miR-143) plays a key role in obesity. Inhibiting miR-143 promotes thermogenesis and combats diet-induced obesity, offering potential therapeutic strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Metabolic Diseases

Background:

  • Obesity is a global epidemic linked to metabolic diseases.
  • MicroRNAs, including miR-143, are implicated as therapeutic targets for obesity.
  • MiR-143 typically promotes adipocyte differentiation by downregulating extracellular signal-regulated kinase 5.

Purpose of the Study:

  • To review the expression and function of miR-143 in various tissues.
  • To examine the impact of obesity on miR-143 levels.
  • To discuss the role of miR-143 in obesity development, thermoregulation, and potential therapeutic applications.

Main Methods:

  • Analysis of miR-143 expression and function in different tissues.
  • Investigation of miR-143 knockout models in diet-induced obesity.
  • Examination of miR-143 regulation by LPS and IL-6 in brown adipocytes.
  • Review of existing literature on miR-143 and obesity.

Main Results:

  • miR-143 knockout counteracts diet-induced obesity by enhancing brown adipose tissue thermogenesis and reducing white adipose tissue adipogenesis.
  • Inhibition of miR-143 in brown adipocytes by LPS or IL-6 boosts thermogenesis via targeting adenylate cyclase 9.
  • Adipose-derived miR-143 significantly influences obesity development.

Conclusions:

  • MiR-143 is a critical regulator in adipose tissue metabolism and thermogenesis.
  • Targeting miR-143 presents a promising avenue for obesity management.
  • Further research into miR-143's role in immune cells and thermoregulation is warranted for therapeutic development.

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