Related Experiment Video
Updated: Aug 17, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
Suicidal ideation in the general population in China after the COVID-19 pandemic was initially controlled
Shuangyan Li1, Shuai Liu1, Puxiao Zhang2
1Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangdong - Hong Kong - Macao Greater Bay Area Center for Brain Science and Brain - Inspired Intelligence, Southern Medical University, Guangzhou, China.
Background:
The COVID-19 pandemic increases the risk of psychological problems including suicidal ideation (SI) in the general population. In this study, we investigated the risk factors of SI after the COVID-19 pandemic was initially controlled in China.
Methods:
We conducted an online questionnaire via JD Health APP in China in June 2020. Demographic data, feelings and experiences related to the COVID-19 pandemic and psychological problems were collected. The participants (n = 14,690) were divided into the non-SI and SI groups. A binary logistic regression analysis was used to examine the correlates of SI.
Results:
Nine percent of the participants (1328/14690) reported SI. The regression analysis showed that SI was positively associated with ethnic minority (OR = 1.42 [1.08-1.85]), age (e.g. 18-30 years: OR = 2.31 [1.67-3.20]), having history of mental disorders (OR = 2.75 [2.27-3.35]), daily life disturbance due to health problems (OR = 1.67 [1.38-2.01]), being around someone with the COVID-19 (OR = 1.58 [1.30-1.91]), being uncertain about effective disease control (OR = 1.23 [1.03-1.46]), and having depressive symptoms (OR = 4.40 [3.59-5.39]), insomnia symptoms (OR = 2.49 [2.13-2.90]) or psychological distress (OR = 1.87 [1.59-2.18]).
Limitations:
The main limitation is that the cross-sectional design of this study could not allow us to further explore the causality of SI.
Conclusions:
The prevalence of SI was relatively high in general population after the COVID-19 pandemic was initially controlled in China. SI should be monitored continually after the COVID-19 pandemic.
Related Concept Videos
Psychological and Sociocultural Causes of Schizophrenia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Controls in Experiments
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Panic Disorder

