Related Experiment Video
Updated: Aug 16, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
Cellular senescence enhances adaptive anticancer immunosurveillance
Ines Marin1, Manuel Serrano1,2, Federico Pietrocola3
1Aging and Metabolism Programme, Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, Spain.
Abstract:
Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neoplastic cells. In this regard, we have recently reported that senescent cancer cells exhibit potent antigenicity and adjuvanticity and can elicit strong CD8+ T cell-dependent anticancer effects when used as vaccination agents.
Related Concept Videos
Replicative Cell Senescence
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cells of the Adaptive Immune Response
Cell-mediated Immune Responses
Tumor Immunotherapy
Abnormal Proliferation

