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Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth

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Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions.

Helge Herthum^1,2,3, Stefan Hetzer^1,2, Bernhard Kreft⁴

¹Berlin Center for Advanced Neuroimaging, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Humboldt-Universität zu Berlin, Berlin, Germany.

Frontiers in Bioengineering and Biotechnology

|December 19, 2022

Summary

Cerebral tomoelastography offers improved brain MRE consistency and resolution. 3D-MRE detects subtle aging effects in white matter over one year, outperforming 2D-MRE in sensitivity to biological changes.

Keywords:

brain human in vivo multifrequency MRE reproducibility viscoelasticity

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Area of Science:

Neuroimaging
Biophysics
Medical Engineering

Background:

Magnetic resonance elastography (MRE) quantifies soft tissue mechanical properties.
Brain MRE data exhibit significant variability and limited resolution.
Existing MRE techniques face challenges in consistency and detail.

Purpose of the Study:

Introduce 2D and 3D cerebral tomoelastography for enhanced brain MRE.
Improve data consistency and detail resolution in brain mechanical property mapping.
Investigate the influence of aging, brain parenchymal fraction (BPF), blood pressure, and BMI on MRE.

Main Methods:

Applied multifrequency MRE with 2D and 3D tomoelastography postprocessing to 31 volunteers.
Analyzed coefficient of variation (CV) and biological factor effects.
Rescanned 11 volunteers after 1 day and 1 year to assess reliability and long-term changes.

Main Results:

3D-MRE showed higher sensitivity to white matter shear wave speed (SWS) decrease over 1 year compared to volume changes.
2D-MRE demonstrated less variation and higher consistency (ICC) over shorter scan times than 3D-MRE.
White matter stiffness correlated with age and BPF, but not with blood pressure or BMI.

Conclusions:

Cerebral tomoelastography yields high-resolution, consistent viscoelasticity maps.
2D-MRE offers better consistency for shorter scans, while 3D-MRE excels in detecting subtle age-related biological changes.
The technique provides a valuable tool for studying brain aging and mechanical properties.