Molecular Target Interactions of Quinoline Derivatives as Anticancer Agents: A Review

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Oncology

Background:

• Cancer remains a leading global cause of death, necessitating novel therapeutic strategies.
• Despite advancements, cancer treatment presents ongoing challenges, driving the search for new anticancer agents.
• Quinoline, a heterocyclic aromatic molecule, and its derivatives are explored for diverse pharmacological activities.

Purpose of the Study:

• To review the anticancer properties of quinoline derivatives.
• To highlight the various molecular targets and mechanisms of action of quinoline-based anticancer drugs.

Main Methods:

• Literature review of quinoline derivatives in cancer research.
• Analysis of documented pharmacological activities and mechanisms of action.

Main Results:

• Quinoline derivatives exhibit a broad spectrum of anticancer activities.
• These compounds act through diverse mechanisms, including inhibition of topoisomerase, tyrosine kinases, Hsp90, and HDACs.
• Other mechanisms include induction of cell cycle arrest, apoptosis, and inhibition of tubulin polymerization.

Conclusions:

• Quinoline derivatives represent a significant class of compounds with demonstrated anticancer potential.
• Their versatile mechanisms of action make them valuable candidates for developing novel cancer therapies.