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Updated: Aug 16, 2025
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Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
Published on: August 23, 2018
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Osteoporosis and Bone Marrow Adipose Tissue.
Kerensa M Beekman1, Gustavo Duque2, Alessandro Corsi3
1Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Current Osteoporosis Reports
|December 19, 2022
Summary
Bone marrow adipose tissue (BMAT) varies significantly with age and sex. Increased BMAT correlates with lower bone density and higher fracture risk, suggesting its potential as a biomarker for osteoporosis.
Area of Science:
- Endocrinology
- Bone Biology
- Radiology
Background:
- Bone marrow adipose tissue (BMAT) content varies individually, by skeletal site, age, and sex.
- Standardized imaging protocols are needed for comparable BMAT quantification.
- Water-fat imaging (WFI) offers an efficient alternative to 1H-MRS for BMAT assessment.
Purpose of the Study:
- Review recent findings on bone marrow adipose tissue (BMAT) and bone health.
- Summarize BMAT variations and update on noninvasive quantification techniques.
- Discuss BMAT's role in osteoporosis and the impact of interventions.
Main Methods:
- Literature review of recent studies on BMAT and bone health.
- Analysis of variations in BMAT across different demographics and skeletal sites.
- Evaluation of noninvasive imaging techniques for BMAT quantification.
Main Results:
- Greater BMAT is linked to lower bone mineral density (BMD) and increased vertebral fractures.
- Proton density fat fraction (PDFF) and lipid composition may serve as fracture risk biomarkers.
- Limited evidence exists on osteoporosis treatments affecting BMAT; romosozumab shows contradictory effects.
Conclusions:
- BMAT is a significant factor in bone health and osteoporosis pathogenesis.
- PDFF and lipid composition show promise as imaging biomarkers for fracture risk.
- Further research is needed to understand BMAT's role and therapeutic targets in osteoporosis.
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