Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2022.2.

Area of Science:

• Clinical Practice Guidelines
• Evidence-Based Medicine
• Oncology

Background:

• Clinical practice guidelines require frequent updates due to rapidly evolving evidence.
• The American Society of Clinical Oncology (ASCO) has developed a methodology for living guidelines.

Purpose of the Study:

• To describe the development and methodology of ASCO Living Guidelines.
• To outline the process for systematic literature review and regular updates.

Main Methods:

• Living guidelines are developed for rapidly evolving topic areas.
• A standing expert panel systematically reviews health literature on a continuous basis.
• Updates are published regularly.

Main Results:

• ASCO Living Guidelines are updated on a regular schedule.
• The guidelines adhere to the ASCO Conflict of Interest Policy.
• Updates are available at https://ascopubs.org/nsclc-da-living-guideline.

Conclusions:

• Living guidelines provide a framework for dynamic clinical practice recommendations.
• These guidelines aim to keep clinical practice aligned with the latest evidence.
• Independent professional judgment and patient variation remain crucial in clinical decision-making.