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A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5

Renaud Pourpre1, Goran Lakisic1, Emma Desgranges1

  • 1Université Paris-Saclay, INRAE, Micalis Institute, EpiMic Lab, Jouy-en-Josas, AgroParisTech, France.

Scientific Reports
|December 19, 2022
PubMed
Summary

The internalin protein P (InlP) from Listeria monocytogenes targets the host cell nucleus. It alters nuclear speckle organization and interacts with the splicing factor RBM5, influencing cell death and granule formation.

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