CEREBRAL OXIMETRY AS A PREDICTOR OF THE OUTCOME OF THE DISEASE IN PATIENTS WITH SECONDARY BRAIN LESIONS

Area of Science:

• Neuroscience
• Critical Care Medicine
• Biomedical Engineering

Background:

• Brain injuries, including vascular and traumatic types, pose significant mortality risks.
• Accurate prognostic indicators are crucial for managing patients in intensive care.
• Cerebral oximetry offers a non-invasive method to assess brain oxygenation.

Purpose of the Study:

• To investigate the prognostic value of cerebral oximetry indicators in predicting mortality.
• To determine the role of cerebral oxygenation in vascular and traumatic brain injuries.
• To establish cut-off values for cerebral oximetry as risk factors for unfavorable outcomes.

Main Methods:

• A prospective cohort study of 129 patients with acute cerebral pathology.
• Monitoring of cerebral gas exchange, oxygenation (rSO2), arteriovenous difference, and neuron-specific markers (S100ß, NSE).
• Analysis of acid-base status and arterial blood gas composition at multiple time points.

Main Results:

• A reduced regional cerebral oxygen saturation (rSO2) below 45% was identified as a significant risk factor for mortality.
• Direct correlations were found between rSO2<45% and elevated S100ß, pneumonia, and specific diagnoses.
• A predictive model demonstrated strong performance (AuROC 0.846) for patient outcomes.

Conclusions:

• Cerebral oximetry, particularly rSO2 levels, serves as a valuable prognostic tool in critical care settings.
• The findings support the use of cerebral oximetry in predicting mortality in patients with vascular and traumatic brain injuries.
• The developed model can assist clinicians in forecasting outcomes for patients with acute cerebral conditions.