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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
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Weighted Heterogeneous Graph-Based Incremental Automatic Disease Diagnosis Method
Yuanyuan Tian1, Yanrui Jin1, Zhiyuan Li1
1State Key Laboratory of Mechanical System and Vibration, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, 200240 China.
Summary
This study introduces an experience-infused knowledge model using incremental learning and knowledge graphs for automatic diagnosis. The novel approach enhances diagnostic accuracy and resists forgetting, outperforming classical models.
Area of Science:
- Artificial Intelligence
- Medical Informatics
- Knowledge Representation
Background:
- Automatic diagnosis models face challenges in classifying numerous diseases and collecting extensive disease-symptom datasets.
- Existing models struggle with scalability and data acquisition for comprehensive diagnostic capabilities.
Purpose of the Study:
- To develop an experience-infused knowledge model for multi-department symptom-based automatic diagnosis.
- To address data collection limitations and large-scale multi-classification issues using knowledge graphs and incremental learning.
Main Methods:
- Constructed a heterogeneous knowledge graph via graph fusion and entity linking.
- Employed incremental learning to continuously update the knowledge graph with experiential knowledge from data.
- Developed adaptive neural network models for each dataset, integrating learned parameters back into the knowledge graph.
Main Results:
- The proposed model demonstrated improved diagnostic accuracy across three public datasets, with average improvements of 5%, 2%, and 15%.
- The model exhibited a strong ability to resist forgetting, maintaining performance on historical data after class increments.
- Incremental learning effectively addressed data collection challenges and enabled scalable multi-classification.
Conclusions:
- The experience-infused knowledge model offers a robust solution for automatic diagnosis, overcoming limitations of traditional approaches.
- Incremental learning and knowledge graph integration are effective strategies for building adaptive and accurate diagnostic systems.
- The model shows significant potential for enhancing clinical decision support systems through continuous learning and knowledge integration.

