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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
Weighted Heterogeneous Graph-Based Incremental Automatic Disease Diagnosis Method
Yuanyuan Tian1, Yanrui Jin1, Zhiyuan Li1
1State Key Laboratory of Mechanical System and Vibration, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, 200240 China.
Abstract:
The objective of this study is to construct a multi-department symptom-based automatic diagnosis model. However, it is difficult to establish a model to classify plenty of diseases and collect thousands of disease-symptom datasets simultaneously. Inspired by the thought of "knowledge graph is model", this study proposes to build an experience-infused knowledge model by continuously learning the experiential knowledge from data, and incrementally injecting it into the knowledge graph. Therefore, incremental learning and injection are used to solve the data collection problem, and the knowledge graph is modeled and containerized to solve the large-scale multi-classification problems. First, an entity linking method is designed and a heterogeneous knowledge graph is constructed by graph fusion. Then, an adaptive neural network model is constructed for each dataset, and the data is used for statistical initialization and model training. Finally, the weights and biases of the learned neural network model are updated to the knowledge graph. It is worth noting that for the incremental process, we consider both the data and class increments. We evaluate the diagnostic effectiveness of the model on the current dataset and the anti-forgetting ability on the historical dataset after class increment on three public datasets. Compared with the classical model, the proposed model improves the diagnostic accuracy of the three datasets by 5%, 2%, and 15% on average, respectively. Meanwhile, the model under incremental learning has a better ability to resist forgetting.

