The efficacy of isosorbide-5-mononitrate on effort-induced electrocardiographic ischemic changes in patients with
D Brunner1, N Meshulam, J Weisbort
1Institute of Physiological Hygiene, Faculty of Medicine, Tel Aviv University, Holon, Israel.
Abstract:
The efficacy of isosorbide-5-mononitrate 40 mg twice a day was tested in 10 patients suffering from effort-induced angina pectoris. Patients were studied with ergometer testing 6 hours after drug administration on the first treatment day, and again 8 and 12 hours after medication at 3 weeks and 6 months of therapy. At comparable and maximal workloads the patients expressed significantly less ST segment depression on treatment than prior to treatment. No tolerance was observed. Isosorbide-5-mononitrate treatment was demonstrated to have a beneficial effect on exercise tolerance in patients suffering from stable angina in effort.
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