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Updated: Aug 16, 2025

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Heterometallic bond activation enabled by unsymmetrical ligand scaffolds: bridging the opposites
R Govindarajan1, Shubham Deolka1, Julia R Khusnutdinova1
1Coordination Chemistry and Catalysis Unit, Okinawa Institute of Science and Technology Graduate University 1919-1 Tancha, Onna-son 904-0495 Okinawa Japan juliak@oist.jp.
Abstract:
Heterobi- and multimetallic complexes providing close proximity between several metal centers serve as active species in artificial and enzymatic catalysis, and in model systems, showing unique modes of metal-metal cooperative bond activation. Through the rational design of well-defined, unsymmetrical ligand scaffolds, we create a convenient approach to support the assembly of heterometallic species in a well-defined and site-specific manner, preventing them from scrambling and dissociation. In this perspective, we will outline general strategies for the design of unsymmetrical ligands to support heterobi- and multimetallic complexes that show reactivity in various types of heterometallic cooperative bond activation.
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