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Updated: Aug 16, 2025
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Manganese-catalyzed hydroarylation of multiple bonds
Rajaram Maayuri1, Parthasarathy Gandeepan1
1Department of Chemistry, Indian Institute of Technology Tirupati, Yerpedu-Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India. pgandeepan@iittp.ac.in.
Abstract:
Transition metal-catalyzed C-H activation has become a promising strategy in organic synthesis due to its improved atom-, step- and resource economy. Considering the Earth's abundance, economic benefits, and low toxicity, 3d metal catalysts for C-H activation have received a significant focus. In particular, organometallic manganese-catalyzed C-H activation has proven to be versatile and suitable for a wide range of transformations such as C-H addition to π-components, arylation, alkylation, alkynylation, amination, and many more. Among them, manganese-catalyzed C-H addition to C-C and C-heteroatom multiple bonds exhibited unique and promising reactivity to construct a wide range of complex organic molecules. In this review, we highlight the developments in the field of manganese-catalyzed hydroarylation of multiple bonds via C-H activation with a range of applications until August 2022.
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