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Visible-Light-Induced Acridinium and Pyridine N-Oxide Dual Catalysis for Direct Acylation of Azauracils with
Lusina Mantry1, Sivakumar Sudharsan1, Parthasarathy Gandeepan1
1Department of Chemistry, Indian Institute of Technology Tirupati, Yerpedu─Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.
Abstract:
A visible-light-driven cross-dehydrogenative coupling of azauracils with aldehydes is described by using dual acridinium photoredox and pyridine N-oxide hydrogen atom transfer catalysis. This oxidant-free method generates acyl radicals under mild conditions, tolerates diverse functional groups, proceeds under air, and is scalable to gram quantities. Mechanistic studies support the selective oxidation of pyridine N-oxide by the photoexcited catalyst, enabling aldehyde activation. This operationally simple protocol provides a sustainable platform for the late-stage functionalization of nitrogen-rich heterocycles.
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