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Microfluidics for diagnosis and treatment of cardiovascular disease
Yonggeng Ma1, Chenbin Liu2, Siyu Cao1
1School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China. gfchen@shu.edu.cn.
Insights
Microfluidic technology offers a low-cost solution for cardiovascular disease (CVD) diagnosis and treatment. This review explores microfluidic devices for detecting CVD markers, modeling cardiovascular systems, and advancing drug delivery.
Area of Science:
- Biomedical Engineering
- Cardiovascular Medicine
- Microfluidics
Background:
- Cardiovascular disease (CVD) is a major global health threat.
- Current CVD diagnosis relies on imaging and biochemical tests with limitations in specificity, range, and cost.
- Microfluidics presents an opportunity to overcome these diagnostic challenges.
Purpose of the Study:
- To review recent advancements in microfluidic applications for cardiovascular disease (CVD) diagnosis and treatment.
- To highlight the potential of microfluidics in early CVD detection and management.
- To discuss the future prospects and challenges of microfluidics in cardiovascular medicine.
Main Methods:
- Review of current literature on microfluidic devices for CVD.
- Analysis of microfluidic applications in CVD marker detection.
- Examination of microfluidic cardiovascular models and drug delivery systems.
Main Results:
- Microfluidic devices show promise for sensitive and specific detection of CVD biomarkers.
- Microfluidic platforms enable the development of realistic cardiovascular models for research.
- Microfluidics facilitates efficient drug screening and targeted delivery for CVD treatment.
Conclusions:
- Microfluidics offers a cost-effective and versatile platform for cardiovascular disease (CVD) diagnosis and treatment.
- Further research and development are needed to fully realize the potential of microfluidics in clinical cardiovascular care.
- Microfluidics is poised to revolutionize early CVD prevention, diagnosis, and therapy.
Abstract:
Cardiovascular disease (CVD), a type of circulatory system disease related to the lesions of the cardiovascular system, has become one of the main diseases that endanger human health. Currently, the clinical diagnosis of most CVDs relies on a combination of imaging technology and blood biochemical test. However, the existing technologies for diagnosis of CVDs still have limitations in terms of specificity, detection range, and cost. In order to break through the current bottleneck, microfluidic with the advantages of low cost, simple instruments and easy integration, has been developed to play an important role in the early prevention, diagnosis and treatment of CVDs. Here, we have reviewed the recent various applications of microfluidic in the clinical diagnosis and treatment of CVDs, including microfluidic devices for detecting CVD markers, the cardiovascular models based on microfluidic, and the microfluidic used for CVDs drug screening and delivery. In addition, we have briefly looked forward to the prospects and challenges of microfluidics in diagnosis and treatment of CVDs.
