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Updated: Aug 30, 2026
Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
Published on: November 30, 2022
Investigation of clinical applicability of deep learning-based virtual contrast-enhanced MRI for nasopharyngeal
Guangping Zeng1,2, Wen Li2, Xue Li3
1Department of Radiation Oncology, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Purpose:
There is a lack of research evaluating the clinical performance of virtual contrast-enhanced MRI (VCE-MRI). This study aims to assess the clinical utility of an established VCE-MRI technique in NPC patients and to establish patient selection criteria.
Materials And Methods:
We retrospectively collected data from 333 NPC patients across six institutions (2012-2023). VCE-MRI was synthesized from T1-weighted and T2-weighted MRI for each patient using the multimodality-guided synergistic neural network (MMgSN-Net), which was pre-trained on a large cohort of 1682 NPC patients from 14 institutions. Three experienced radiologists independently assessed image quality using a 5-point Likert scale, with scores below 4 deemed clinically unacceptable. The association between assessment results and patient clinical characteristics of corresponding patients (tumor diameter, T-stage, shape, gender, age) was analyzed to stratify the patients suitable for MMgSN-Net-based VCE-MRI.
Results:
Clinically acceptability of VCE-MRI significantly decreased with larger tumor diameters (p=0.001), advanced T-stage (T1: 100%, T2: 95.1%, T3: 90.0%, T4: 69.6%; p<0.001), and complex tumor shape (regular: 94.8% vs. complex: 74.0%; p<0.001). Age and gender had no significant impact (p=0.327, 0.773). 13 unacceptable patients were found due to severe VCE-MRI artifacts. VCE-MRI achieved high clinical acceptability in T1/T2 patients (109/114, 95.6%) and T3/T4 patients with regular tumor shapes (115/120, 95.8%). In contrast, acceptability significantly decreased to 73.0% (65/89) for T3/T4 tumors with complex shapes. The T-staging result discordance rate between VCE-MRI and CE-MRI is 8.4%, with overstaging in 15 cases.
Conclusion:
MMgSN-Net-based VCE-MRI demonstrates favorable clinical feasibility in selected patient subgroups, T1/T2-stage NPC and T3/T4-stage NPC with regular tumor morphology, potentially reducing GBCAs administration in 67.3% of eligible patients when applying these stratification criteria.