[Evaluation and clinical practice of vestibular function tests in acoustic neuroma]

Objective:This study was conducted to evaluate the applications of vestibular function tests in diagnosis, identifying tumor origins and prognosis of vestibular rehabilitation of patients with acoustic neuroma. Methods:This research is a single-center cross-sectional clinical study, which retrospectively analyzed the data of 335 patients with acoustic neuroma from March 2013 to March 2020 in the Eye and ENT Hospital of Fudan University. The study included caloric test, cervical and ocular vestibular evoked myogenic potentials（cVEMP, oVEMP）, video head impulse test（vHIT） and sensory organization test（SOT）. Firstly, the sensitivity, specificity, and Yoden index of each test were calculated. Secondly, the internal relevance of these tests was studied for application in judging the origins of the tumor. Results:The abnormal rates of caloric test, cVEMP, oVEMP, vHIT and SOT was 85.3%, 86.1%, 85.5%, 55.6% and 67.7% in these participants. Among all the vestibular function tests included, the caloric test showed the best sensitivity（0.855）, specificity（0.981）, and Yoden index（0.836）. The study found that the higher the Koos grades, the higher the abnormal rates of the caloric test, vHIT, and oVEMP（Cochran-Armitage test, P<0.05）. There was no significant relationship between the combination of abnormal vestibular function tests and tumor origin nerves（P>0.05）. Conclusion:Majorlty of the participants in this study with acoustic neuroma showed abnormal results in SOT related to poor balance control. More than half of the patients had at least two abnormal result of the battery of vestibular function tests, among which the caloric test was proved to have better sensitivity and specificity. The higher the Koos grades of the tumor, the higher the abnormal rates of the caloric test, vHIT, and oVEMP.