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Factors producing elevated core temperature in spontaneously hypertensive rats.

M G Collins1, W S Hunter, C M Blatteis

  • 1Physiology Department, Southern Illinois University, Carbondale 62901.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 1, 1987
PubMed
Summary

Spontaneously hypertensive rats (SHR) exhibit higher core body temperatures due to increased metabolic heat production. This elevation in temperature is not compensated by changes in thermal conductance or evaporative heat loss, leading to hyperthermia in SHR.

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Area of Science:

  • Physiology
  • Thermoregulation
  • Cardiovascular Research

Background:

  • Spontaneously hypertensive rats (SHR) exhibit a consistently higher core body temperature (Tco) by approximately 1°C compared to normotensive controls.
  • Understanding the physiological factors contributing to this elevated Tco in SHR is crucial for cardiovascular and thermoregulatory research.

Purpose of the Study:

  • To investigate the underlying physiological mechanisms responsible for the elevated core body temperature in spontaneously hypertensive rats (SHR) compared to Wistar-Kyoto (WKY) rats.
  • To analyze factors including metabolic heat production, evaporative heat loss, and thermal conductance across a range of ambient temperatures.

Main Methods:

  • Measurements of core body temperature, skin temperature, metabolic heat production, respiratory evaporative heat loss, effective tissue thermal conductance, and blood pressure were conducted.

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  • Experiments involved male SHR and WKY rats exposed to various ambient temperatures (12.5°C to 35°C) under controlled conditions.
  • Steady-state physiological parameters were determined for both rat groups.

    • Main Results:

    • SHR consistently displayed higher systolic blood pressure, core body temperature, and metabolic heat production across all tested ambient temperatures compared to WKY rats.
    • SHR maintained thermal balance up to an ambient temperature of 32°C, while WKY rats could tolerate up to 34°C.
    • While evaporative heat loss was greater in SHR at lower ambient temperatures, effective tissue thermal conductance did not significantly differ or was higher in SHR, failing to compensate for increased heat production.

    Conclusions:

    • The elevated core body temperature in SHR is primarily attributed to increased metabolic heat production.
    • This heightened heat production is not adequately compensated by increased effective tissue thermal conductance or evaporative heat loss.
    • These findings highlight a thermoregulatory deficit in SHR contributing to their characteristic hyperthermia.