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Updated: Aug 16, 2025
Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
Published on: March 4, 2021
Retinal toxicity of long term overdose of sildenafil citrate: A case report
Huichao Yan1,2,3,4, Wenzhen Yu1,2,3,4
1Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
Purpose:
To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate.
Observations:
A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil citrate at a dose of 200 mg daily for two years. mERG and OCT examination revealed persistent damage of retinal photoreceptor cells. The symptoms did not disappear after 3 months off the medication.
Conclusions And Importance:
Long term excessive use of overdose sildenafil citrate can cause serious damage to retinal photoreceptor cells. The retinal side effects of sildenafil citrate still need to be further investigated, and the administration of systemic overdose also needs to be considered by all physicians, not just ophthalmologists.
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