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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.2K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Stem Cell Niche01:26

Stem Cell Niche

5.2K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Updated: Aug 16, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Guiding stem cells for cutaneous repair.

Shivani Desai1, Juilee Jagtap2, Shivani Sainani2

  • 1Serum Institute of India Pvt. Ltd., Pune, India.

Current Research in Pharmacology and Drug Discovery
|December 22, 2022
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for tissue repair, but their effectiveness in patients is uncertain. This review explores methods to guide these stem cells for better skin repair outcomes.

Keywords:
Clinical efficacyCutaneous repairMesenchymal stem cellsStem cell guidingStem cell niche

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Tissue Engineering

Background:

  • Mesenchymal stem cells (MSCs) are recognized for their regenerative potential due to proliferation, differentiation, and paracrine secretion capabilities.
  • While MSC safety is established in clinical trials, their therapeutic efficacy for tissue repair remains a challenge.
  • The microenvironment, or 'niche,' significantly influences MSC behavior and function post-transplantation.

Purpose of the Study:

  • To review methods for directing mesenchymal stem cells (MSCs) for enhanced cutaneous repair.
  • To address the need for guided stem cell activity in therapeutic applications.

Main Methods:

  • Review of existing literature on mesenchymal stem cell (MSC) biology and transplantation.
  • Analysis of factors influencing MSC viability, function, and in-vivo performance.
  • Exploration of strategies to control the MSC microenvironment and cell fate.

Main Results:

  • MSC efficacy is contingent upon viability, secretome function, and the in-vivo transplantation context.
  • The MSC niche, comprising physical, chemical, and biological cues, is critical for regulating stem cell fate.
  • Current challenges include directing the function of scaled-up MSCs for targeted therapeutic outcomes.

Conclusions:

  • Guiding mesenchymal stem cells (MSCs) is essential for optimizing their therapeutic potential in cutaneous repair.
  • Further research into controlling the MSC niche and directing cell activity is crucial for improving stem cell therapy efficacy.