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Updated: Aug 16, 2025
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
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Sulphur Containing Heterocyclic Compounds as Anticancer Agents.
Balwinder Kaur1, Gurdeep Singh1, Vikas Sharma1
1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144001, India.
Anti-Cancer Agents in Medicinal Chemistry
|December 22, 2022
Summary
This review highlights sulfur-containing heterocyclic compounds as promising anticancer agents. Thiophene, thiazole, and thiadiazole derivatives show significant potential in inhibiting cancer cell proliferation.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Oncology
Background:
- Cancer is a leading global cause of death, necessitating novel therapeutic strategies.
- Heterocyclic compounds are crucial in drug discovery due to their structural diversity.
- Sulfur-containing compounds play vital roles in biological systems and are of interest in cancer research.
Approach:
- This review focuses on sulfur-containing heterocyclic compounds with anticancer properties.
- It examines the role of sulfur in biological processes, including nucleic acid and tRNA modification.
- Recent studies on thiophene, thiazole, and thiadiazole derivatives are highlighted.
Key Points:
- Sulfur's biological significance extends to its role in anticancer research.
- Thiophene derivatives have demonstrated potent anti-proliferative activity against breast cancer cells.
- Azole structures, including thiazole and thiadiazole, are increasingly recognized for their anticancer potential.
Conclusions:
- Sulfur-containing heterocyclic compounds represent a promising class of anticancer agents.
- Further research into these compounds could lead to new cancer therapies.
- The versatility of these structures offers opportunities for drug development.
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