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Updated: Aug 16, 2025

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of
Maria-Alexandra Paun1,2, Mihai-Virgil Nichita3, Vladimir-Alexandru Paun4
1School of Engineering, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Vaud, Switzerland.
Abstract:
Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological viewpoint via Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The SEM images of the formulations were investigated in concordance with fractal analysis, and the fractal dimensions and lacunarity were computed. The developed mathematical multifractal model is necessarily confirmed by the experimental measurements corresponding to the 5-fluorouracil release outside the chitosan-formed matrix.

