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Biomimetically Engineered Amyloid-Shelled Gold Nanocomplexes for Discovering α-Synuclein Oligomer-Degrading Drugs

Dongtak Lee1, Hyo Gi Jung1,2, Dongsung Park1,3

  • 1School of Biomedical Engineering, Korea University, Seoul02841, South Korea.

ACS Applied Materials & Interfaces
|December 22, 2022
PubMed

Keywords:
Parkinson’s diseaseamyloid coronadrug screeningplasmonic nanoparticleα-synuclein

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...