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Decoupling Individual Optical Nanosensor Responses Using a Spin-Coated Hydrogel Platform.

Matthew Card1, Raisa Alejandro1, Daniel Roxbury1

  • 1Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island02886, United States.

ACS Applied Materials & Interfaces
|December 22, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a new hydrogel platform for single-walled carbon nanotubes (SWCNTs) to improve biosensing. This method offers enhanced sensitivity and spatial resolution for detecting analytes like sodium deoxycholate (SDC).

Keywords:
hydrogelhyperspectral imagingnear-infrared fluorescenceoptical sensorssingle-molecule detection

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Area of Science:

  • Nanotechnology
  • Biomedicine
  • Materials Science

Background:

  • Single-walled carbon nanotubes (SWCNTs) possess unique properties utilized in nanotechnology and biomedicine.
  • SWCNTs function as near-infrared fluorescence sensors for detecting biologically relevant analytes in solution.
  • Current solution-based sensing methods using SWCNTs suffer from limited sensitivity and spatial resolution.

Purpose of the Study:

  • To develop an improved platform for analyzing individual SWCNTs in their native aqueous state.
  • To investigate the temporal modulations of SWCNTs in response to a model analyte at the single-molecule level.
  • To demonstrate enhanced sensitivity and spatial resolution compared to solution-phase SWCNT sensing.

Main Methods:

  • Devised a spin-coated poly(ethylene glycol) diacrylate (PEG-DA) hydrogel platform.
  • Examined individual DNA-functionalized SWCNTs (DNA-SWCNTs) within the hydrogel.
  • Introduced sodium deoxycholate (SDC) as a model analyte to study DNA-SWCNT interactions and spectral responses.

Main Results:

  • Observed time-dependent spectral modulations in emission center wavelengths and peak intensities of individual SWCNTs upon SDC addition.
  • Found a significant delay in peak intensity modulations compared to center wavelength modulations, suggesting decoupled responses.
  • Utilized a 1-D diffusion model to correlate SDC concentration with SWCNT spectral responses, creating dose-response curves.

Conclusions:

  • The PEG-DA hydrogel platform enables sensitive, single-molecule analysis of SWCNTs in an aqueous environment.
  • The study demonstrates multiparameter analyte detection through distinct spectral modulations.
  • This platform offers a significant improvement in sensitivity and modifiability over solution-phase SWCNT sensing techniques.