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Updated: Jan 25, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Meningitis caused by vancomycin-resistant Leuconostoc sp
Y M Coovadia1, Z Solwa, J van den Ende
1Department of Microbiology, University of Natal Medical School, Durban, South Africa.
Abstract:
A rare case of purulent meningitis caused by vancomycin-resistant Leuconostoc sp. is reported. The patient was treated successfully with penicillin G, and there were no neurological sequelae. We recommend that all gram-positive cocci isolated from cerebrospinal fluid and blood be fully identified so as not to confuse Leuconostoc spp. with more commonly isolated pathogens such as pneumococci and other alpha-hemolytic streptococci.
Insights
A rare case of meningitis caused by vancomycin-resistant Leuconostoc was successfully treated with penicillin G. Accurate identification of gram-positive cocci is crucial to distinguish Leuconostoc from common pathogens.
Area of Science:
- Infectious Diseases
- Microbiology
- Neurology
Background:
- Meningitis is a serious infection of the central nervous system.
- Leuconostoc species are gram-positive cocci, rarely causing invasive infections.
- Vancomycin resistance is an emerging challenge in treating bacterial infections.
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