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Graphene Oxide-based Endodontic Sealer: An in Vitro Study
Mohammed Zahedul Islam Nizami1,2,3, Melahat Gorduysus1,4, Yuki Shinoda-Ito1
1Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Acta Medica Okayama
|December 22, 2022
Summary
New graphene oxide (GO) composites show promise as advanced endodontic sealers. These materials offer effective sealing, radiopacity, and bioactivity, potentially improving root canal treatment success and preventing reinfection.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Nanotechnology in Dentistry
Background:
- Endodontic treatment failure is often linked to microbial infections in root canals.
- Developing bactericidal and biocompatible endodontic sealers is crucial for successful root canal therapy.
- Current clinical challenges necessitate innovative solutions for effective root canal sealing.
Purpose of the Study:
- To evaluate the efficacy of graphene oxide (GO) composites (GO-CaF2 and GO-Ag-CaF2) as novel endodontic sealer materials.
- To assess the sealing ability, radiopacity, and bioactivity of these GO-based composites in vitro.
- To compare the performance of GO composites with conventional zinc oxide sealers.
Main Methods:
- In vitro assessment of GO-CaF2 and GO-Ag-CaF2 composites as endodontic sealers on dentin slices.
- Evaluation of sealing effect after immersion in saline, PBS, and SBF at 37°C for 24 hours.
- Analysis of radiopacity and mineral deposition using scanning electron microscopy and radiographic imaging.
Main Results:
- Scanning electron microscopy confirmed significant sealing capabilities of the GO-based composites.
- Radiographic images demonstrated adequate radiopacity, meeting sealer requirements.
- Evidence of mineral deposition indicated bioactivity, particularly for GO-Ag-CaF2, suggesting regenerative potential.
Conclusions:
- Graphene oxide composites (GO-CaF2 and GO-Ag-CaF2) exhibit promising properties for endodontic sealers.
- These materials demonstrate effective sealing, radiopacity, and bioactivity, alongside previously established bactericidal and cytocompatible characteristics.
- GO-based composites offer a potential advancement for preventing reinfection and enhancing overall success in root canal treatments.
