Related Experiment Video
Updated: Aug 16, 2025

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
Published on: January 31, 2025
TFEB-associated renal cell carcinoma: A case report and literature review
Yong Zhu1, Chengxing Xia1, Yitian Ou1
1Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Rationale:
TFEB-associated renal cell carcinoma is very rare and belongs to the microphthalmia - associated transcription family translocation renal cell carcinoma.
Patient Concerns:
Hospitalized for fever, a 29-year-old male patient had a left kidney lesion without any additional discomfort.
Diagnoses:
Histopathological and immunohistochemical results were corresponding with TFEB renall cell carcinoma features.
Interventions:
Surgical resection of the tumor was performed.
Outcomes:
After 8 months of follow-up, no tumor recurrence was observed.
Lessons:
TFEB-associated renal cell carcinoma is rare. The diagnosis is explicit. However, the optimal treatment needs to be further explored.
Related Concept Videos
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

