Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

3.5K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
3.5K
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

10.6K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An innovative cellular medicine approach via the utilization of novel nanotechnology-based biomechatronic platforms as a label-free biomarker for early melanoma diagnosis.

Scientific reports·2024
Same author

On-Chip Terahertz Spectroscopy for Dual-Gated van der Waals Heterostructures at Cryogenic Temperatures.

Nano letters·2024
Same author

Encapsulating commercial accelerometers with epoxy and fluoroelastomer for harsh hydrocarbon fluid environment.

Scientific reports·2023
Same author

Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays for High-Throughput Large-Scale Sample Inspection.

Journal of visualized experiments : JoVE·2023
Same author

Building block 3D printing based on molecular self-assembly monolayer with self-healing properties.

Scientific reports·2022
Same author

Quantification and reduction of Poisson-Gaussian mixed noise induced errors in ellipsometry.

Optics express·2021

Related Experiment Video

Updated: Aug 16, 2025

Contact Mode Atomic Force Microscopy as a Rapid Technique for Morphological Observation and Bacterial Cell Damage Analysis
05:34

Contact Mode Atomic Force Microscopy as a Rapid Technique for Morphological Observation and Bacterial Cell Damage Analysis

Published on: June 30, 2023

1.5K

Review: Advanced Atomic Force Microscopy Modes for Biomedical Research.

Fangzhou Xia1, Kamal Youcef-Toumi1

  • 1Mechatronics Research Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Biosensors
|December 23, 2022
PubMed
Summary

New Atomic Force Microscopy (AFM) functionalities enable high-speed imaging, force spectroscopy, and nano-manipulation for visualizing complex biological systems at the nanoscale. These advanced AFM capabilities offer unprecedented insights into dynamic processes and molecular interactions in biomedical research.

Keywords:
atomic force microscopybiomedical researchhigh-speed imagingmaterial property mappingmechanobiologynano-manipulationnanotechnology

More Related Videos

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays
05:04

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays

Published on: June 13, 2023

1.7K
Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
08:41

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

40.2K

Related Experiment Videos

Last Updated: Aug 16, 2025

Contact Mode Atomic Force Microscopy as a Rapid Technique for Morphological Observation and Bacterial Cell Damage Analysis
05:34

Contact Mode Atomic Force Microscopy as a Rapid Technique for Morphological Observation and Bacterial Cell Damage Analysis

Published on: June 30, 2023

1.5K
Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays
05:04

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays

Published on: June 13, 2023

1.7K
Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
08:41

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

40.2K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Microscopy

Background:

  • Microscopic visualization of native biomedical samples is vital for understanding complex biological systems.
  • Studying dynamic biological processes requires advanced microscopy with high resolution, large imaging ranges, and in-situ manipulation.
  • Atomic Force Microscopy (AFM) has emerged as a powerful tool in biological and biomedical research.

Purpose of the Study:

  • To review novel functionalities of Atomic Force Microscopy (AFM) for biological and biomedical research.
  • To highlight AFM's capabilities in high-speed imaging, mechanobiology, molecular characterization, and nano-manipulation.
  • To demonstrate the effectiveness of advanced AFM techniques through recent application examples.

Main Methods:

  • Review of recent advancements in Atomic Force Microscopy (AFM) techniques.
  • Focus on novel functionalities including high-speed imaging, force spectroscopy, and nano-manipulation.
  • Analysis of selected application examples from current scientific studies.

Main Results:

  • Novel AFM functionalities significantly enhance the visualization of dynamic biological processes.
  • AFM enables detailed mechanobiology studies and molecular species characterization.
  • AFM nano-manipulation capabilities open new avenues for nanoscale research and exploration.

Conclusions:

  • Advanced AFM techniques provide unprecedented capabilities for observing and exploring nanoscale biological and biomedical processes.
  • These functionalities facilitate novel scientific research by offering high spatial/temporal resolution and versatile imaging environments.
  • AFM is a transformative tool for advancing fundamental biological principles and discovering complex biomedical systems.