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Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

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Label-Free Bound-States-in-the-Continuum Biosensors.

Man Luo¹, Yi Zhou¹, Xuyang Zhao¹

¹The Key Laboratory of Micro and Nano Photonic Structures, Department of Optical Science and Engineering, Fudan University, Shanghai 200438, China.

|December 23, 2022

Summary

This summary is machine-generated.

Bound states in the continuum (BICs) offer infinite quality factors for highly sensitive label-free biosensing. This review explores BIC-based optical biosensors using various materials and structures for advanced detection.

Keywords:

bound states in the continuum label-free nanostructures optical biosensors

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Area of Science:

Photonics and Nanotechnology
Biomedical Sensing
Optical Physics

Background:

Bound states in the continuum (BICs) possess theoretically infinite quality (Q)-factors.
High-Q factors enable enhanced light-matter interactions, crucial for sensitive detection.
BICs are promising for label-free biosensing applications due to their sensitivity to refractive index changes.

Purpose of the Study:

To review recent advancements in label-free optical biosensors utilizing BICs.
To categorize BIC biosensors based on their constituent materials and structural designs.
To discuss current challenges and future outlook for BIC-inspired biosensors.

Main Methods:

Review of literature on BIC-based biosensors.
Categorization of sensors by material composition (dielectric, metal, hybrid).
Classification of sensors by structural implementation (grating, metasurfaces, photonic crystals).

Main Results:

BIC biosensors demonstrate high sensitivity for label-free detection.
Diverse material platforms (dielectric, metal, hybrid) are employed.
Various structures including gratings, metasurfaces, and photonic crystals support BICs for sensing.

Conclusions:

BIC-based optical biosensors represent a significant advancement in label-free sensing technology.
The choice of material and structure critically influences sensor performance.
Further research is needed to overcome current challenges and fully realize the potential of BIC biosensors.