Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-Performance Guided Mode Resonance Optofluidic Sensor.

Sensors (Basel, Switzerland)·2025

Same author

An all-optical multidirectional mechano-sensor inspired by biologically mechano-sensitive hair sensilla.

Nature communications·2024

Same author

Label-Free Bound-States-in-the-Continuum Biosensors.

Biosensors·2022

Same author

Optical Whispering-Gallery-Mode Microbubble Sensors.

Micromachines·2022

Same author

Ultrahigh Sensitivity Mach-Zehnder Interferometer Sensor Based on a Weak One-Dimensional Field Confinement Silica Waveguide.

Sensors (Basel, Switzerland)·2021

Same author

Wide and continuous dynamic tuning of period, modulation depth and duty cycle of a laminar-flow-based microfluidic grating.

Lab on a chip·2021

Same journal

A Coumarin-Based Probe for Sequential ON-OFF-ON Detection of Cu<sup>2+</sup> and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging.

Biosensors·2026

Same journal

Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.

Biosensors·2026

Same journal

Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Biosensors·2026

Same journal

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data.

Biosensors·2026

Same journal

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026

Same journal

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 12, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Sensitivity Equalization and Dynamic Range Expansion with Multiple Optofluidic Microbubble Resonator Sensors.

Ye Wang¹, Xuyang Zhao¹, Liying Liu¹

¹Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Fudan University, Shanghai 200433, China.

|October 27, 2023

Summary

This summary is machine-generated.

A new method equalizes signals from optofluidic microbubble resonators (OMBRs), enabling direct comparison and enhancing biosensing. This technique achieves wide dynamic range detection for HIV-1 p24 antigen, showing potential for disease diagnosis.

Keywords:

HIV-1 p24 WGM biosensing optofluidic

More Related Videos

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Published on: May 29, 2014

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Related Experiment Videos

Last Updated: Jul 12, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Published on: May 29, 2014

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Area of Science:

Optofluidics
Biosensing
Nanophotonics

Background:

Optofluidic microbubble resonators (OMBRs) are sensitive biosensors.
Variations in OMBR fabrication can lead to inconsistent sensing signals.
Direct comparison of signals from different OMBRs is challenging.

Purpose of the Study:

To present a novel sensitivity equalization method for OMBRs.
To enable direct comparison of sensing signals from individual OMBRs.
To demonstrate a wide dynamic range and reliable biosensing for HIV-1 p24 antigen detection.

Main Methods:

Developed a sensitivity equalization method based on the ratio of wavelength shifts to bulk refractive index sensitivity (BRIS).
Experimentally validated the method to confirm signal equalization.
Integrated signals from 20 OMBRs to achieve a wide dynamic range.

Main Results:

The equalization method proved effective, allowing direct comparison of signals from different OMBRs.
Achieved a wide dynamic range for HIV-1 p24 antigen detection, from 50 fg/mL to 100 ng/mL (2.1 fM to 4.2 nM).
Demonstrated favorable consistency and repeatability in sensing signals.

Conclusions:

The novel equalization method overcomes signal variations in OMBRs.
This technique significantly enhances the potential for practical biosensing applications.
The method is promising for drug screening and disease diagnosis, exemplified by HIV-1 p24 antigen detection.