Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

132
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
132
Layers of Connective Tissue Proper01:21

Layers of Connective Tissue Proper

2.0K
Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing...
2.0K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.7K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.2K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.2K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

324
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
324
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

511
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral Nerve Stimulation of the Sacral Lateral Branches for Sacroiliac Joint Pain: A Technical Report.

Pain practice : the official journal of World Institute of Pain·2026
Same author

Updated 2026 Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.

Pain physician·2026
Same author

Neurovascular Compression Syndromes of Cranial Nerves: A Multidisciplinary Guide to Management.

Brain sciences·2026
Same author

A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Epidural Regenerative Medicine Therapies in Managing Spinal Pain.

Current pain and headache reports·2026
Same author

The Utility of Caudal Epidural Steroid Injections: A Comprehensive Review.

Orthopedic reviews·2026
Same author

Radiofrequency ablation of C2-3 medial branches/third occipital nerve to treat cervicogenic headache.

Annals of palliative medicine·2026
Same journal

Precision Proteomic Profiling of Systemic Lupus Erythematosus-Correlating Disease Activity and Complement Levels with Clinical Phenotypes.

Biomedicines·2026
Same journal

The Role of Salivary Microbiota in Pancreatic Cancer: From Screening to Tumor Progression and Treatment Response.

Biomedicines·2026
Same journal

Diagnostic Utility of Surface Electromyography for Identifying Muscles Affected by Myofascial Trigger Points: A Scoping Review.

Biomedicines·2026
Same journal

Performance Assessment of a Locally Semi-Automated NGS-Based Workflow for Homologous Recombination Deficiency Testing in High-Grade Serous Ovarian Carcinoma.

Biomedicines·2026
Same journal

Coupling and Uncoupling Pleiotropy Between Hypertension and Type 2 Diabetes Contribute to Exploring Potential Heterogeneity in Cardiovascular Risk in East Asian Population.

Biomedicines·2026
Same journal

Maternal Response to Therapeutic Plasma Exchange in Early Gestation: A Case Series of Thrombotic Microangiopathies and Neurological Disorders.

Biomedicines·2026
See all related articles

Related Experiment Video

Updated: Aug 16, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.3K

Fibromyalgia Pathophysiology.

Michael Gyorfi1, Adam Rupp2, Alaa Abd-Elsayed1

  • 1Department of Anesthesia, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.

Biomedicines
|December 23, 2022
PubMed
Summary
This summary is machine-generated.

Fibromyalgia pathogenesis involves biological, genetic, and environmental factors affecting pain processing. Understanding these fibromyalgia triggers can lead to better treatment options.

Keywords:
affective spectrum disordersfibromyalgiapathophysiologysmall fiber neuropathy

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

304

Related Experiment Videos

Last Updated: Aug 16, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.3K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

304

Area of Science:

  • Neuroscience
  • Genetics
  • Environmental Health

Background:

  • Fibromyalgia symptoms may stem from altered pain inhibition and sensory processing.
  • Genetic predisposition and familial aggregation are observed in fibromyalgia and related disorders.
  • Environmental stressors and neuroendocrine dysfunction can influence pain processing.

Purpose of the Study:

  • To examine the biological, genetic, and environmental factors contributing to fibromyalgia pathogenesis.
  • To explore the relationship between endogenous pain inhibition, central sensory processing, and fibromyalgia.
  • To identify potential targets for improved fibromyalgia treatment strategies.

Main Methods:

  • Review of existing biological, genetic, and environmental research on fibromyalgia.
  • Analysis of studies on pain processing, autonomic nervous system function, and neuroendocrine responses.
  • Examination of familial aggregation studies for fibromyalgia and associated conditions.

Main Results:

  • Evidence suggests aberrations in endogenous pain inhibition and central sensory processing in fibromyalgia.
  • Genetic studies indicate familial links between fibromyalgia, major depressive disorder, and other conditions.
  • Physical and psychological stressors, autonomic dysfunction, and neuroendocrine changes are implicated in fibromyalgia pathophysiology.

Conclusions:

  • Fibromyalgia pathogenesis is multifactorial, involving complex interactions between genetic and environmental influences.
  • Further research into the pathophysiology of fibromyalgia is crucial for developing targeted therapies.
  • A comprehensive understanding of fibromyalgia's biological underpinnings will enhance patient treatment outcomes.