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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Oncolytic Adenovirus, a New Treatment Strategy for Prostate Cancer

Kaiyi Yang1, Shenghui Feng2, Zhijun Luo2

  • 1Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.

Biomedicines
|December 23, 2022
PubMed

Insights

Human adenovirus (HAdV)-based gene therapy offers a promising new avenue for treating advanced prostate cancer, particularly metastatic castration-resistant prostate cancer (mCRPC) when other treatments fail. Ongoing research explores HAdV

Area of Science:

  • Oncology
  • Virology
  • Gene Therapy

Background:

  • Prostate cancer is a leading cause of cancer mortality in men.
  • Androgen-deprivation therapy (ADT) is effective but resistance develops in 10-50% of cases, leading to metastatic castration-resistant prostate cancer (mCRPC).
  • Current salvage treatments for advanced prostate cancer have suboptimal outcomes.

Purpose of the Study:

  • To review the potential of human adenovirus (HAdV)-based gene and viral therapy for prostate cancer.
  • To summarize the advantages of oncolytic virus therapy and HAdV modification strategies.
  • To evaluate preclinical and clinical investigations of HAdV in prostate cancer treatment.

Main Methods:

  • Review of existing literature on oncolytic virus therapy.
  • Analysis of HAdV modification strategies for cancer treatment.
  • Summary of preclinical and clinical studies involving HAdV for prostate cancer.

Main Results:

  • HAdV-based therapies demonstrate potent oncolytic effects in preclinical studies.
  • Clinical trials are underway to assess the efficacy and safety of HAdV in prostate cancer.
  • HAdV offers potential for treating castration-resistant and advanced prostate cancer, alone or combined with other modalities.

Conclusions:

  • Oncolytic adenovirus-mediated gene therapy presents a promising therapeutic strategy for advanced prostate cancer.
  • Further clinical investigation is warranted to establish the role of HAdV in mCRPC treatment.
  • Targeting prostate cancer with HAdV, potentially combined with radiotherapy and chemotherapy, offers new hope for patients.
Keywords:
gene therapyhuman adenovirusimmunotherapyoncolytic virusprostate cancer

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