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Published on: February 15, 2015
P3b Amplitude and Latency in Tic Disorders: A Meta-Analysis
Yue Yang1, Hua Yang1, Yao Deng1
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Abstract:
P3b is an event-related potential (ERP) that may be abnormal in patients with tic disorders (TD), but evidence has been inconsistent. Given the possible association between P3b and TD and the need for biomarkers for TD, the primary objective of this meta-analysis was to characterize P3b in patients with TD in comparison to healthy controls (HCs).
Methods:
By searching PubMed, Embase, Web of Science, SCOPUS, Medline, and Google Scholar, we identified studies that compared P3b between TD patients and HCs. The amplitude and latency of P3b were then analyzed. Subgroup analyses were conducted to investigate the influence of different experimental factors on P3b indices.
Result:
Overall, 19 articles involving 388 cases and 414 controls were evaluated. There were no significant abnormalities in P3b amplitude and latency in TD patients. The P3b amplitude of the TD patients was significantly decreased during the oddball task, and the P3b amplitude of the adult TD patients was also significantly decreased.
Conclusion:
TD patients may have an abnormal P3b compared to HCs under specified conditions.
