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Modeling of Red Blood Cells in Capillary Flow Using Fluid-Structure Interaction and Gas Diffusion.

Ling An1, Fenglong Ji2, Yueming Yin1

  • 1School of Engineering, Dali University, Dali 671003, China.

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|December 23, 2022
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Deformable red blood cells (RBCs) exhibit reduced gas diffusion. Clustered RBCs significantly lower diffusion capability compared to evenly dispersed cells, impacting pulmonary diffusing capacity.

Keywords:
capacity flowcell clusteringcell deformationdiffusion capacity

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Area of Science:

  • Physiology
  • Biophysics
  • Computational Biology

Background:

  • Pulmonary diffusing capacity is influenced by red blood cell (RBC) distribution, shape, and flow.
  • Understanding gas exchange dynamics within capillaries is crucial for respiratory health.

Purpose of the Study:

  • To simulate gas diffusion into deformable RBCs within capillaries.
  • To investigate the impact of RBC deformation and clustering on diffusion capacity.

Main Methods:

  • Utilized a gas diffusion model.
  • Employed the immersed finite element method for simulations.
  • Modeled gas diffusion into deformable RBCs in capillary flow.

Main Results:

  • Simulations revealed nonuniform CO flux across the membrane of deformed RBCs.
  • Deformable RBCs demonstrated a reduced capacity for gas diffusion.
  • Clustered RBCs showed significantly lower diffusion capability compared to evenly dispersed RBCs.

Conclusions:

  • RBC deformation and clustering negatively affect pulmonary diffusing capacity.
  • Computational modeling provides insights into microcirculatory gas exchange mechanisms.
  • Findings highlight the importance of RBC morphology and distribution for efficient oxygen transport.