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Laxative consumption in chronic nonorganic constipation.

E Corazziari1, E Materia, G Bausano

  • 1Cattedra di Gastroenterologia I, Clinica Medica II, Università La Sapienza, Roma, Italy.

Journal of Clinical Gastroenterology
|August 1, 1987
PubMed
Summary
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Laxative use is common in chronic constipation, but habitual use didn't improve bowel habits or transit time. While easing evacuations, laxatives caused side effects without relieving constipation symptoms.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Chronic constipation affects a significant portion of the population.
  • Laxative use is prevalent among patients with chronic constipation.
  • The efficacy and impact of habitual laxative use on gastrointestinal physiology remain areas of investigation.

Purpose of the Study:

  • To investigate the relationship between laxative consumption and bowel habits.
  • To assess the impact of laxatives on total gastrointestinal transit time (TGITT).
  • To evaluate the effect of laxatives on constipation-related symptoms.

Main Methods:

  • Retrospective analysis of patient data on laxative use.
  • Correlation of laxative intake patterns with bowel frequency and TGITT.
  • Assessment of symptom changes in relation to laxative consumption.

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Main Results:

  • 87.9% of patients used laxatives, with 30% using them habitually.
  • Habitual laxative use increased with age and duration of constipation.
  • No significant correlation found between laxative intake and bowel frequency or TGITT.
  • Laxatives improved evacuation but caused diarrhea and mucus.
  • No improvement in abdominal or extra-abdominal symptoms was observed.

Conclusions:

  • Habitual laxative use in chronic nonorganic constipation does not significantly improve objective measures like bowel frequency or TGITT.
  • Laxatives may offer symptomatic relief for evacuation difficulty but can lead to adverse effects.
  • Further research is needed to explore alternative or adjunctive therapies for chronic constipation.