Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis-Literature Review

Area of Science:

• Cardiovascular Medicine
• Biomarker Discovery
• Molecular Pathophysiology

Background:

• Atherosclerosis poses a significant long-term burden on the cardiovascular system.
• Effective management relies on traditional and emerging biomarkers to assess disease progression.
• Detecting incipient vascular lesions requires advanced predictive marker models.

Purpose of the Study:

• To analyze recent literature on molecular mechanisms of biomarkers in atherosclerosis.
• To understand the role of biomarkers in the atherosclerotic cascade.
• To explore the linkage between lipid profiles, inflammation, and disease evolution.

Main Methods:

• Literature review of recent data.
• Analysis of molecular mechanisms of biomarkers.
• Investigation of biomarker involvement in atherosclerotic pathophysiology.

Main Results:

• Advances have strengthened the understanding of the lipid profile-inflammation link.
• Biomarkers are crucial for evaluating atherosclerotic stages and early lesions.
• The study synthesizes current knowledge on molecular pathways.

Conclusions:

• Biomarker research is vital for understanding and managing atherosclerosis.
• Improved predictive models are needed for early vascular lesion detection.
• A comprehensive view of lipid-inflammation interplay aids therapeutic strategies.